Imaging tumor angiogenesis with fluorescent proteins
نویسندگان
چکیده
منابع مشابه
Multimodality Imaging of Tumor Angiogenesis: Perfusion Modeling for Tumor Angiogenesis
When a tracer, such as Gd-doped or iodinated extracellular contrast, is introduced into the blood stream of a patient its transport through the vascular system, heart and lungs and eventual excretion via the kidneys is a well-established process [1,2]. At the level of the imaging voxel (for example, in the centre of a breast tumor) we can only speculate as to the precise nature of the tracer ki...
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Molecular imaging has recently been defined by the Society of Nuclear Medicine as ‘the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems’ (Mankoff 2007). It usually exploits specific labeled molecular probes, as well as intrinsic tissue characteristics as the source of image contrast, and uses a numbe...
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Angiogenesis is a multistep process regulated by pro- and antiangiogenic factors. In order to grow and metastasize, tumors need a constant supply of oxygen and nutrients. For growth beyond 1-2 mm in size, tumors are dependent on angiogenesis. Inhibition of angiogenesis is a new cancer treatment strategy that is now widely investigated clinically. Researchers have begun to search for objective m...
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We report here a novel transgenic nude mouse for the visualization of human tumor angiogenesis. We have recently shown that the neural stem cell marker nestin is expressed in hair follicle stem cells and blood vessel networks in the skin of C57/B6 transgenic mice with nestin regulatory element– driven green fluorescent protein (ND-GFP). Others have shown ND-GFP is expressed in the brain, pancre...
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ژورنال
عنوان ژورنال: APMIS
سال: 2004
ISSN: 0903-4641,1600-0463
DOI: 10.1111/j.1600-0463.2004.t01-1-apm11207-0805.x